VP, Head of Global Supply Chain

Our culture is entrepreneurial, inclusive and caring. We're passionate about our work. And we embrace a pioneering spirit. Join us as we strive to develop innovative therapies with the power to give people with genetic diseases freedom for life.

Job Summary

The Head of Global Supply Chain will develop and implement end-to-end supply chain strategy, operational plans, KPIs and objectives across all programs at the company. This leader ensures seamless cross-functional coordination to meet clinical and commercial requirements, ensure timely supply of gene therapy products and services to markets/patients, and optimize Supply Chain results. The Head of Global Supply Chain will establish and build the supply chain function working closely with Manufacturing, Quality, Regulatory Affairs and Commercial. 

Cambridge
Research and Development
Key Responsibilities

Function Build:

  • Develops long-term strategies to establish and maintain a robust clinical and commercial supply chains, enact appropriate risk mitigation procedures, and monitor and identify future market trends.
  • Define, execute and lead strategic initiatives for supply chain forecasting and management, including cost reduction and risk reduction opportunities, inventory optimization and other activities related to warehousing of materials and materials management improvements (including but not limited to inventory management systems development).
  • Partner with Medical, Clinical and Commercial to identify demand assumptions, such as enrollment rate, number of sites, number of countries, sales forecasts, launch planning to develop supply requirements plans.
  • Consistently perform duties within established SOPs, and in accordance with GxP requirements, where applicable

Production & Capacity Planning:

  • Establishes and drives the Sales & Operations Planning process including both Commercial/Clinical demand forecasting and production planning.
  • Lead end to end supply chain business processes which include Demand Planning and Forecasting, Direct Material Procurement, Expediting, Supply Planning, Master Scheduling and Inventory Management.
  • Develop user requirements and work cross functionally to implement an enterprise resource planning system

Logistics Management:

  • Establish cold chain shipping, distribution, and trade strategy and processes.
  • Establishes chain of custody / chain of identity systems for logistics of patient material.
  • Qualify logistics providers and set up the supply chain including courier selection, container validation, etc.
  • Own the relationship with 3PL distributors and qualified external supply chain partners.
  • Monitor inventory levels at depots/clinical sites through the life of a trial and/or commercial sales; take preventative actions to avoid potential supply issues
  • Manage all drug product shipping, labeling and distribution to worldwide clinical sites/commercial sites using a network of vendors
  • Coordinate shipments of in-process GMP materials and released clinical materials between vendors and storage sites
  • Support country logistics for shipping and importation, on assigned study or program
  • Anticipate risks and identify proactive measures to mitigate issues

Materials Management:

  • Establishes and maintains a system for managing supply of materials that includes specifying, purchasing, receiving, testing, releasing, and using materials
  • Establishes and executes material planning procedures to ensure a consistent supply of materials to meet the production plan both near term and long range. The output of the materials plan includes planned purchases and production events (e.g. media & kits)
  • Works with Purchasing, Manufacturing, and Quality to establish and maintain a reliable supplier network to provide the best value to the organization
  • Partner with Manufacturing and Quality to conduct risk assessment and supplier audit / qualification. Use risk-based approach to determine preferred supplier and materials supply/inventory strategy

Sourcing and supply network strategy:

  • Leads supply chain sourcing/procurement and supports overall operations strategies assessment include make/buy evaluations, scenario planning, supply impact assessment and network supply strategy

Performance Management:

  • Accountable for defining and reporting Supply Chain Performance Management
  • Proactively identify, develop, and implement reporting and analytics to support the monitoring of overall supply chain performance
  • Measure, trend and report supply related KPIs as a basis to drive continuous improvement
Minimum Requirements/ Qualifications
  • Minimum Bachelor’s degree in Engineering, Supply Chain, or related field
  • At least 15 years of experience in managerial capacity in Supply Chain or Head of Supply Unit (Pharmaceuticals, Biopharmacetical or Biotechnology). Experience in autologous gene or cell therapy strongly desired.
  • Demonstrated ability to work across global markets
  • Excellent knowledge of Supply Chain business processes within pharmaceutical manufacturing operations, with exposure to both commercial and production
  • Demonstrated ability to lead cross-functional teams, influence and manage key stakeholders, and build strong working relationships
  • Ability to work and thrive in a fast paced, rapidly changing environment
  • High performing, credible professional, with a track record of successfully managing multiple projects and achieving results in line with an established strategy
  • Knowledge of production, quality and regulatory requirements within the pharmaceutical industry, including autologous therapies
  • Working knowledge of ERP systems, supply chain planning/management/optimization applications, and Lean concepts
  • Proven understanding of global chain-of-custody and distribution requirements and best practices.
  • Outstanding interpersonal verbal, written, and presentation skills with internal and external stakeholders
  • Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective.
About AVROBIO

AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON.

AVROBIO, Inc is an EEO employer