Program Leader

Our culture is entrepreneurial, inclusive and caring. We're passionate about our work. And we embrace a pioneering spirit. Join us as we strive to develop innovative therapies with the power to give people with genetic diseases freedom for life.

Job Summary

AVROBIO is seeking a highly capable Program Leader who is passionate about drug development and inspired by the prospect of joining a company whose vision is to bring personalized gene therapy to the world.

We are looking for a motivated professional with strong leadership and program management skills to drive the advancement of gene therapy programs in AVROBIO’s pipeline. The Program Leader will work collaboratively to develop overall strategy and operational plans, and to orchestrate key activities of diverse functions (research, preclinical, clinical/medical, manufacturing, operations, regulatory affairs, commercial, business development, finance, etc.). This is a unique opportunity to play a key leadership role on a team whose aim is to halt or reverse disease with a single dose of gene therapy. 

Program Management
Key Responsibilities
  • Leads the cross-functional program team, working closely with team members and functional subject matter experts.  
  • Orchestrates the development of overall program strategy and the associated integrated development plan (IDP). 
  • Drives communications, decision-making, and issue resolution across respective program sub-teams, functions, and governance forums.  
  • Maintains a fully integrated, cross-functional program view, inclusive of all critical path activities and key development and commercialization milestones. 
  • Prepares and delivers governance proposals and regular updates for AVROBIO’s senior management and Board of Directors.
  • Conducts program risk assessments and ensures timely escalation and resolution of issues. 
  • Fosters a culture of accountability, positive team dynamics, and cross-functional collaboration.
  • Collaborates with cross-functional stakeholders to identify platform synergies across the portfolio and share lessons learned. 
  • Identifies, establishes, and promotes best practices for program management across teams.
Minimum Requirements/ Qualifications
  • Strong leadership and collaboration skills; demonstrated success as both a team leader and team player.  
  • 10+ years of experience in a biopharma environment. Advanced degree (MD, PhD, MS, MBA) strongly desired.
  • 8+ years in program management leadership roles, managing cross-functional drug development efforts in gene therapy, biologics, small molecules, or medical devices.
  • Strong knowledge and understanding of global drug development. Experience in rare disease and lysosomal disorders a plus. 
  • Strong influencing, negotiation, and interpersonal skills.
  • Demonstrated ability to lead teams in a matrixed environment.
  • Proven ability to facilitate cross-functional strategy development and issue resolution.  
  • Excellent oral and written communication skills.
  • Experience in all phases of drug development (Preclinical through registration and commercialization) a plus.
  • Experience in ex vivo cell or gene therapies a plus.

AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON.

AVROBIO, Inc is an EEO employer