Scientist I

Cambridge, MA
Posted 3 months ago

In this position you will work as part of a small team conducting laboratory research activities to support our preclinical stage development programs for lentiviral-based gene therapies focusing on rare diseases, where a faulty gene results in a lack of an essential enzyme or protein.

Key Responsibilities

  • Scientist responsible for working on genetic modification of mouse and human hematopoietic stem cells (HSCs) (HSC’s).
  • Work in a dynamic scientific environment collaborating with peer scientists or working independently.
  • Solve challenging scientific problems.
  • Awareness of and ability to comply with all laboratory safety and documentation requirements.
  • Present data within Avrobio and to broader scientific community as appropriate.


  • Experience with molecular biology, including lentiviral vectors, CRISPR/Cas9 gene editing, Western blotting, cell culture, transfections, biochemical assays, flow cytometry, qPCR required.
  • In vivo experience with transplantation of gene-modified HSCs as well as lysosomal storage disorders a preference.
  • Proven experience excelling in a dynamic scientific environment.
  • Ability to adapt to research outcomes.
  • Excellent scientific writing skills.


  • PhD in Molecular Medicine or Stem Cell Biology preferred; Master’s Degree and previous related experience may be considered


  • Passport required for occasional international travel

To apply, email your resume to:
AVROBIO, Inc is an EEO employer

About AVRO
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON

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