AVROBIO, a recently public gene therapy company based in Cambridge, MA, seeks an experienced, accomplished, and collaborative General Counsel to join us as the Company’s first in-house counsel. In this role she/he will lead the Company’s legal function, provide a broad spectrum of legal counsel, and serve as a contributing member of the Company’s Executive team. We are seeking an individual with strong technical/analytical skills, combined with a practical, business-oriented, and strategic approach to identifying and solving business and legal problems as the company grows and evolves. He/she should be a seasoned professional who exhibits sound judgement, is decisive, and makes informed decisions. Strong personal values and the highest level of integrity are essential. 

Key Responsibilities:

  • Act as an advisor to the Board of Directors and its committees on matters of corporate governance, including serving as Corporate Secretary.
  • Support the Company’s various functions, including Manufacturing, Business Development, IT, Human Resources, Commercial, Finance, Facilities, etc.
  • Oversee the structuring and negotiation of business agreements and contracts, including strategic alliances, joint ventures, licenses, R&D, CRO, supply, manufacturing, distribution, merger/acquisition agreements, real estate, and government contracts.
  • Oversee the departments’ paralegal and administrative contract functions.
  • Manage compliance with corporate and securities rules and regulations, including the preparation and filing of SEC Forms 10-K, 10-Q, and 8-K, financial releases, proxy materials and other related filings.
  • Direct, manage, and optimize work with internal and external legal staff, including budgeting and tracking utilization of outside counsel.
  • Advise Human Resources department and senior staff regarding employment law and compensation issues, including administration of equity compensation plans.
  • Develop new and improve existing Company policies and processes that support business objectives and intelligently manage compliance and risk.
  • Work with the finance department to establish and implement appropriate disclosure controls and procedures to ensure that compliance with obligations under the Securities & Exchange Act of 1934 and the Sarbanes-Oxley Act of 2002.
  • Develop and oversee appropriate legal risk systems for global operations, including regulatory, FCPA, select agent and securities laws.

Minimum Requirements/Qualifications:

  • JD with a strong academic record; admitted to the Massachusetts or New York Bar.
  • 12+ years corporate and life science law experience, including several years’ experience at a nationally recognized law firm with a focus on public offerings and advising public companies on SEC, regulatory and securities matters.
  • Previous legal leadership expertise working cross-functionally internally, externally and managing a small team.
  • Proven experience structuring, negotiating, and drafting corporate agreements and contracts demonstrating good judgment and reputation for high ethical standards.
  • Substantial experience advising business personnel and senior management on corporate and securities compliance matters; detailed knowledge of SEC reporting requirements and regulations, including periodic and current reports and Section 16 and Sarbanes-Oxley requirements.
  • Proven experience with corporate risk management activities in a public biotech company.
  • Experience working with and advising public company boards of directors and board committees on day to day governance issues, including preparing for and attending board meetings; up to date and knowledgeable of current corporate governance best practices.

To apply, email your resume to: jobs@avrobio.com

AVROBIO, Inc is an EEO employer

About AVRO
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON

The Director/Senior Director of Financial Planning and Analysis will report to and be a strategic partner to the CFO. This is a hand on position and the individual will work cross functionally within AVRO to provide leadership in strategic financial planning, budgeting, the alignment of resources and evaluation of business opportunities to enable the achievement of strategic goals. The position will have responsibility for financial planning and financial modeling, as well as other business analyses to support key company initiatives and objectives.

Key Responsibilities:

  • Lead company-wide Financial Planning and Analysis process, including annual budget and quarterly financial forecast and cash forecasting
  • Work closely with the Controller and finance operations team to ensure planning inputs and functional reviews are carried out with accuracy and timeliness
  • Work closely with the CFO to craft messages and presentations to senior management and the Board. Preparation of Executive and Board presentations
  • As leader of FP&A ensure process and system consistency and continuous improvement of monthly Budget vs. Actual reporting process
  • Work cross-functionally with the CFO and senior management on the evaluation of strategic and business alternatives
  • Provide hands-on development of financial models to support strategic planning, financing alternatives, business and tax scenarios and other corporate initiatives
  • Analyze and present financial reports in an accurate and timely manner; prepare and consolidate reporting materials; clearly communicate monthly and annual financial performance
  • Develop financial and non-financial key performance indicators. Identify opportunities to improve and streamline existing business processes and decision making
  • Effectively communicate critical financial matters to the CFO and senior executives
  • Coordinate business reviews and implement key follow-ups
  • Work with the CFO to optimize business deliverables, enhance team dynamics and culture
  • Coordinate efforts for company initiatives and partner with other functions and operations leads

Minimum Requirements/Qualifications:

  • Bachelor’s Degree, MBA required
  • Minimum 10 -15 years of related industry experience in Corporate Finance, Business Analytics and/or Investment Banking
  • An excellent understanding of the biotechnology industry and the various functional areas; previous experience in financial planning and analysis and operations in a life sciences/biotech company
  • Must present a high degree of professionalism in both written and verbal communication; ability to work effectively with senior executives and the board
  • Proven problem-solving skills and ability to achieve successful outcomes and identify process improvement
  • A strong working knowledge of corporate capital fundraising alternatives and business and tax structures
  • Strong analytical skills with experience evaluating and analyzing complex financing and business initiatives
  • Experience working within a public company environment
  • Experience with M&A, public company and licensing valuation modeling
  • High degree of initiative with the ability to work effectively, both cross-functionally and independently is required
  • Strong interpersonal skills and a team player is essential
  • Excellent computer modeling and presentation skills (Advanced Excel, Word and PowerPoint skills are required)

To apply, email your resume to: jobs@avrobio.com
AVROBIO, Inc is an EEO employer

About AVRO
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON

The Executive Assistant to the CFO is responsible for performing a wide array of administrative functions, as well as special projects, requiring a high degree of integrity, initiative, and resourcefulness. This position requires an individual with strong organizational and analytical skills, able to balance competing and changing priorities with a learned understanding of related business needs in a fast-paced environment. Given that daily activities often involve access to sensitive, non-public information, this position also requires sound judgment, confidentiality, and the ability to act as a gatekeeper. In this role, the assistant will interface with internal and external parties on behalf of the CFO and the Finance team, including but not limited to Board of Directors, outside counsel, investors and investment bankers, and other Wall Street participants.

Key Responsibilities:

  • Manage complex calendars, scheduling requests, and appointments for the CFO and Finance team, coordinating internal and external calls, meetings, interviews, department programs, events, and conferences, including invitations, rooms, and catering.
  • Work collaboratively with Investor Relations consultant related to logistics and materials for conferences and roadshows, as well as maintaining investor database on SharePoint and providing reports as requested.
  • Reviews incoming correspondence, initiates replies as appropriate, brings attention to matters requiring action by the executive or their teams and follows up to ensure completion, providing a weekly summary of outstanding items.
  • Develop new and modify existing PowerPoint presentations and spreadsheets using appropriate template/branding materials, maintaining electronic and physical files in an orderly and retrievable fashion.
  • Arrange domestic and international travel, including air, hotel, and ground transportation, as well as visa processing, and international invitation letters.
  • Coordinate various Board Committee meetings, materials, and written communications.
  • Prepare and reconcile expense reports, manage vendors, review invoices, and follow contract and purchase order procedures to facilitate payment.
  • Assist with preparation of quarterly budget reviews.
  • Update department databases, including relevant contact information.
  • Ad hoc projects as directed.

Minimum Requirements/Qualifications:

  • Minimum 5 years’ experience in a C-level executive administrative support capacity, preferably for CFO or CEO of a public company.
  • Associates Degree or equivalent combination of education and experience.
  • Knowledge of public company financial and investor procedures strongly preferred.
  • Knowledge of administrative procedures and best practices, proficient with MS Office Suite including Outlook, Word, Excel and PowerPoint.
  • Must present a high degree of professionalism in both written and verbal communication.
  • Strong problem-solving skills and ability to work both independently, as well as cross-functionally, to achieve successful outcomes and identify process improvements.
  • Sound judgment and ability to prioritize.
  • Able to multi-task, observe office policies and procedures, and meet deadlines while maintaining a high level of organization and exceptional attention to detail.
  • Able to handle confidential material with discretion.

To apply, email your resume to: jobs@avrobio.com
AVROBIO, Inc is an EEO employer

About AVRO
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON

In this position you will work as part of a small team conducting laboratory research activities to support our preclinical stage development programs for lentiviral-based gene therapies focusing on rare diseases, where a faulty gene results in a lack of an essential enzyme or protein.

Key Responsibilities

  • Scientist responsible for working on genetic modification of mouse and human hematopoietic stem cells (HSCs) (HSC’s).
  • Work in a dynamic scientific environment collaborating with peer scientists or working independently.
  • Solve challenging scientific problems.
  • Awareness of and ability to comply with all laboratory safety and documentation requirements.
  • Present data within Avrobio and to broader scientific community as appropriate.

Qualifications

  • Experience with molecular biology, including lentiviral vectors, CRISPR/Cas9 gene editing, Western blotting, cell culture, transfections, biochemical assays, flow cytometry, qPCR required.
  • In vivo experience with transplantation of gene-modified HSCs as well as lysosomal storage disorders a preference.
  • Proven experience excelling in a dynamic scientific environment.
  • Ability to adapt to research outcomes.
  • Excellent scientific writing skills.

Education

  • PhD in Molecular Medicine or Stem Cell Biology preferred; Master’s Degree and previous related experience may be considered

Other

  • Passport required for occasional international travel

To apply, email your resume to: jobs@avrobio.com
AVROBIO, Inc is an EEO employer

About AVRO
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical-stage company developing disruptive therapies that have the potential to transform patients’ lives with a single dose. The Company is focused on the development of its gene therapy candidate, AVR‑RD‑01, in Fabry disease, as well as additional gene therapy programs in other lysosomal storage disorders including Gaucher disease, Cystinosis and Pompe disease. AVROBIO’s lentiviral platform has broad potential for other rare and non-rare genetic diseases. AVROBIO is headquartered in Cambridge, MA and has offices in Toronto, ON